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. 2016 Nov 16;6:37184. doi: 10.1038/srep37184

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Tenotomy mice were treated by local injection of Cx43 shRNA or intraperitoneal injection of U0126. HO tissues were decalcified, and expression of Cx43, p-ERK, ERK, Runx2 and BSP was detected by immunohistochemistry at week 8. (B) Cx43, p-ERK, Runx2 and BSP expression in the HO tissues was quantified.