Fig. 2.

Formation of repair tissue after 12 weeks of co-cultivation. Histological appearance of repair tissue formed after 12 weeks of co-cultivation with implanted spheroids of a co-culture of patient #8. HE stained cross section of a standardized subchondral cartilage defect until tidemark (arrowhead) showing the presence of a disintegrated implanted spheroid (S). Newly formed regenerative tissue (RT) covered by a newly formed multilayer of cells (ML). The formed repair tissue is well integrated in the neighbouring native cartilage (NC). Scale bar 500 µm. ML multilayer, NC native cartilage, S spheroid, SB subchondral bone, RT regenerative tissue