Table 2.
Spheroid characteristics | Correlation with level of tissue regeneration and statistical significance |
---|---|
ACAN protein | r = 0.55; p < 0.025 |
ACAN mRNA | r = 0.53; p < 0.05a |
GAG spheroids | ns |
GAG medium | ns |
GAG ratio | r = 0.41; p = 0.073 |
S100BmRNA | ns |
CRTAC1 mRNA | ns |
Spearman’s correlation coefficient r was calculated between spheroid characteristics analysed before implantation and the capacity of tissue regeneration after 12 weeks of co-cultivation in an ex vivo cartilage repair model
ns not significant
aACAN mRNA levels do correlate with tissue regeneration when one statistical outlier (#12) with extremely high ACAN mRNA levels is taken out of the analysis