Table 3.
DEGs or 22q11.2 genes with the most co-expressed genes in different brain regions*
| Brain Region | Embryonic | Adolescence | ||
|---|---|---|---|---|
| DEGs | 22q11.2 | DEGs | 22q11.2 | |
| FC | KIAA1467 | CDC45 | HERC3 | CRKL |
| MAPKAPK3 | COMT | DDX3X | PRODH | |
| CHD1L | TXNRD2 | MTMR7 | DGCR6 | |
| SEPT2 | SLC25A1 | ELL2 | LZTR1 | |
| RFXANK | THAP7-AS1 | LRRTM3 | C22orf29 | |
| SC | SCAF11 | CDC45 | PJA2 | C22orf39 |
| KHNYN | SLC25A1 | ZMYM2 | MED15 | |
| MAPKAPK3 | CLDN5 | DPP8 | PRODH | |
| TP53 | COMT | PDCD6IP | HIRA | |
| LAMC3 | CRKL | B4GALT6 | TANGO2 | |
| SM | PLIN3 | CDC45 | PDCD6IP | COMT |
| FGFR2 | CRKL | HDAC7 | DGCR6 | |
| RREB1 | THAP7-AS1 | UBE3C | CRKL | |
| MAPKAPK3 | COMT | LRFN5 | PRODH | |
| MCAM | SEPT5 | GLRB | SLC25A1 | |
| TP | FGFR2 | SLC25A1 | MEF2A | COMT |
| MAP7D3 | CDC45 | NRXN1 | DGCR6 | |
| PLIN3 | RANBP1 | FBXO45 | CRKL | |
| MAPKAPK3 | SCARF2 | PDCD6IP | PRODH | |
| TP53 | SNAP29 | MTMR7 | SLC25A1 | |
| Total | MAPKAPK3 | CDC45 | PDCD6IP | PRODH |
| PLIN3 | SLC25A1 | MTMR7 | DGCR6 | |
| SCAF11 | COMT | GLRB | COMT | |
*In each stage and region, DEGs or 22q11 deleted genes were ranked according to their numbers of connection with other DEGs. The top three genes in the “Total” had the highest numbers of connections summed over all four regions in the embryonic or adolescence stages