Table 2.
Up- and down- regulated genes in airway epithelium of ‘healthy smokers’ reported
| Epithelium | Gene symbol | Description | Regulation (HSa/NSb) | Reference |
|---|---|---|---|---|
| SAEc/LAEd | G6pd | glucose-6-phosphatedehydrogenase | up | Carolan et al. [78], Hackett et al. [79] |
| SAE/LAE | GCLC | Glutamate-cysteineligase, catalytic subunit | up | Carolan et al. [78], Hackett et al. [79], Spira et al. [82] |
| SAE/LAE | GPx2 | Glutathioneperoxidase 2 | up | Carolan et al. [78], Hackett et al. [79], Harvey et al. [80], Turetz et al. [81], Spira et al. [82], Zhang et al. [83] |
| SAE | GSR | Glutathionereductase | up | Carolan et al. [78], Hackett et al. [79] |
| SAE/LAE | ADH7 | Alcoholdehydrogenase 7, mu or sigmapolypeptide | up | Carolan et al. [78], Hackett et al. [79], Harvey et al. [80], Turetz et al. [81], Spira et al. [82] |
| SAE/LAE | AKR1B1 | aldo-keto reductasefamily 1, memberB1 | up | Carolan et al. [78], Hackett et al. [79], Harvey et al. [80], Spira et al. [82], Zhang et al. [83] |
| SAE/LAE | AKR1C | aldo-keto reductasefamily 1, memberC | up | Carolan et al. [78], Hackett et al. [79], Harvey et al. [80], Turetz et al. [81], Spira et al. [82], Zhang et al. [83] |
| SAE | TXNRD1 | Thioredoxinreductase 1 | up | Carolan et al. [78], Hackett et al. [79], Spira et al. [82] |
| SAE | PGD | Phosphogluconatedehydrogenase | up | Carolan et al. [78], Hackett et al. [79] |
| SAE | TALDO1 | transaldolase 1 | up | Carolan et al. [78], Hackett et al. [79] |
| SAE | CYP1B1 | cytochrome P450, family 1, subfamilyB, polypeptide1 | up | Carolan et al. [78], Hackett et al. [79], Harvey et al. [80], Spira et al. [82], Zhang et al. [83] |
| SAE/LAE | CX3CLI | Chemokine(C-X3-C motif)ligand 1 | down | Harvey et al. [80], Turetz et al. [81], Spira et al. [82] |
| SAE/LAE | ALDH3A1 | Aldehydedehydrogenase 3family, memberA1 | up | Harvey et al. [80], Turetz et al. [81], Spira et al. [82] |
| SAE/LAE | NQO1 | NAD(P)Hdehydrogenase, quinone 1 | up | Harvey et al. [80], Spira et al. [82], Zhang et al. [83] |
| LAE | SLIT | slit homolog (Drosophila) | up | Turetz et al. [81], Spira et al. [82] |
| SAE | UCHL1 | Ubiquitincarboxylterminal, esteraseL1 | down | Harvey et al. [80], Spira et al. [82] |
aHS: healthy smokers, bNS: nonsmokers
cSAE: small airway epithelium, dLAE: large airway epithelium