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. 2016 Nov 15;13:291. doi: 10.1186/s12974-016-0757-6

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Effects of selective inhibition of CSF1R activity on the disease progression. a. Time-course of the neurological disability score of EAE and EAE + GW2580 animals is reported in the graph (mean ± SD), showing the peak at day 11 (acute phase), the remission phase at day 16, and relapse at day 18 for EAE animals while a delayed and reduced clinical score was observed for EAE + GW2580 group. b The body weight gain (mean ± SD) is reported in the graph (mean ± SD), enlightening a significant difference between GW2580 and EAE + GW2580 group. c Cumulative disability index. Statistical analysis: a, b two-way ANOVA and Bonferroni post-test (***P < 0.001); c one-way ANOVA, ****P < 0.0001