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. 2016 Jul 25;16(10):e37806. doi: 10.5812/hepatmon.37806

Table 2. Amino Acid Substitutions in the HBs- Ag with Known and Unknown Functional Effects.

Codon /Position aa Substitution Frequency, % Vaccinated frq, % Function References
AGT/GGT - 160 S54G 1 (1.63) 100 Unknown
TGT/TAT - 227 C76Y 1 (1.63) 0 Unknown
TTC/TGC - 254 F85C 1 (1.63) 0 Unknown
ATC /ACC - 275 I92T 2 (3.27) 0 Unknown
TTG/TTT - 312 L104F 1 (1.63) 100 Unknown
ATT/CTT - 330 I110L 1 (1.63) 0 Unknown
AGC/GGC - 349 S117G 1 (1.63) 100 Escape (26)
ACC/GTC - 367 T123V 1 (1.63) 0 Unknown
ACG/ATG -368 T125M 1 (1.63) 0 Escape (26)
CCT/ACT - 379 P127L/T 2 (3.27) 50 Escape (27)
CAA/CAC - 387 Q129H 21 (34.42) 35.3 Escape, detection, Ig therapy (26)
TCG/TTG - 428 S143L 1 (1.63) 0 Escape (9)
GAC/GAA - 432 D144E 1 (1.63) 0 Escape, detection, Ig therapy (28)
GAG/GAT - 492 E164D 1 (1.63) 0 Escape (26)
TGG/ CGG - 493 W165R 1 (1.63) 0 Unknown
GCC/ GTC - 503 A168V 5 (8.2%), 20 Unknown