Table 2. Amino Acid Substitutions in the HBs- Ag with Known and Unknown Functional Effects.
| Codon /Position | aa Substitution | Frequency, % | Vaccinated frq, % | Function | References |
|---|---|---|---|---|---|
| AGT/GGT - 160 | S54G | 1 (1.63) | 100 | Unknown | |
| TGT/TAT - 227 | C76Y | 1 (1.63) | 0 | Unknown | |
| TTC/TGC - 254 | F85C | 1 (1.63) | 0 | Unknown | |
| ATC /ACC - 275 | I92T | 2 (3.27) | 0 | Unknown | |
| TTG/TTT - 312 | L104F | 1 (1.63) | 100 | Unknown | |
| ATT/CTT - 330 | I110L | 1 (1.63) | 0 | Unknown | |
| AGC/GGC - 349 | S117G | 1 (1.63) | 100 | Escape | (26) |
| ACC/GTC - 367 | T123V | 1 (1.63) | 0 | Unknown | |
| ACG/ATG -368 | T125M | 1 (1.63) | 0 | Escape | (26) |
| CCT/ACT - 379 | P127L/T | 2 (3.27) | 50 | Escape | (27) |
| CAA/CAC - 387 | Q129H | 21 (34.42) | 35.3 | Escape, detection, Ig therapy | (26) |
| TCG/TTG - 428 | S143L | 1 (1.63) | 0 | Escape | (9) |
| GAC/GAA - 432 | D144E | 1 (1.63) | 0 | Escape, detection, Ig therapy | (28) |
| GAG/GAT - 492 | E164D | 1 (1.63) | 0 | Escape | (26) |
| TGG/ CGG - 493 | W165R | 1 (1.63) | 0 | Unknown | |
| GCC/ GTC - 503 | A168V | 5 (8.2%), | 20 | Unknown |