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TERT promoter mutation reactivates the silenced TERT promoter via generating long-range chromatin interactions. Ak1nc1lar and colleagues (1) show that TERT reactivation by the proximal promoter mutation is directly mediated by a novel long-range chromatin interaction between the TERT promoter and a 300 kb upstream region (chr5: 1,556,087-1,558,758). GABPA proteins might generate long-range chromatin interactions by linking the mutant TERT promoter and the specific interacting region.
