Table 1.

Summary of Published Hsp70 Inhibitor Scaffolds

Scaffold	Nomenclature (Compound Name)	Compound Structure	Hsp70/DnaJ Inhibitory Activity Reported	Hsp70 Family member targeted	Anti-Tau Activity Reported
Rhodacyanine	3-benzyl-2-((Z)-((E)-5-(6- chloro-3- methylbenzo[d]thiazol-2(3H)- ylidene)-3-ethyl-4- oxothiazolidin-2- ylidene)methyl)thiazol-3-ium chloride (JG-98)		(Li et al., 2013; Rousaki et al., 2011)	HSPA8 (Hsc70); HSPA9 (Mortalin); HSPA1 (Hsp72); SSA1 (Hsp70 yeast) DnaK (Hsp70 Bacterial)	(Fontaine et al., 2015; Rousaki et al., 2011)
Dihydropyrimidine	4-[1,1'-Biphenyl]-4-yl-3,4- dihydro-6-methyl-2-oxo-5- [(phenylmethoxy)carbonyl]- 1(2H)-pyrimidinehexanoic acid (116-9E)		(Chang et al., 2008; Wisen et al., 2010)	DnaK (Hsp70 Bacterial)	Unknown
Phenothiazine	3,7- bis(Dimethylamino)phenazat hionium chloride (Methylene Blue)		(Chang et al., 2008; Jinwal et al., 2009; Miyata et al., 2012)	HSPA1 (Hsp72)	(Jinwal et al., 2009; Wischik, Edwards, Lai, Roth, & Harrington, 1996)
Piperidine-3-Carboxamide	(S)-N-(1-propyl-1H- benzimidazol-2-yl)-1-(2- pyrazinyl)piperidine-3- carboxamide (HS72)		(Howe et al., 2014)	HSPA1 (Hsp72)	Unknown
Adenosine Analog	5'-O-[(4- Cyanophenyl)methyl]-8- [[(3,4- dichlorophenyl)methyl]amino ]-adenosine (VER-155008)		(Williamson et al., 2009)	HSPA8 (Hsc70); HSPA1 (Hsp72)	Unknown
Phenoxy-N-Arylacetamide	butyl 3-[2-(2,4- dichlorophenoxy)acetamido] benzoate (ALSB-2970)		(Cassel, llyin, McDonnell, & Reitz, 2012)	targets and binds to DNAJ	Unknown
Sulfonamide	2-Phenylethynesulfonamide (PES)		(Leu, Pimkina, Frank, Murphy, & George, 2009)	HSPA1 (Hsp72) DnaK (Hsp70 Bacterial)	Unknown
Flavonol	3,3',4',5,5',7- Hexahydroxyflavone (Myricetin)		(Chang et al., 2008; Chang et al., 2011; Jinwal et al., 2009)	HSPA8 (Hsc70) DnaK (Hsp70 Bacterial)	(Jinwal et al., 2009)