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. 2016 Nov 17;1(19):e88632. doi: 10.1172/jci.insight.88632

Figure 3. Quantification of the neurons differentiated from the engrafted hiPSC-pNPCs.

Figure 3

(A–D) The percentage of Dcx-, NeuN-, GABA-, and Tbr1-expressing cells in the hN+ cells in different brain regions from 3 weeks to 13 months (n = 6 for each time point). All quantitative data are analyses of pooled data collected from transplantation of hiPSC1- and hiPSC2-pNPCs. (E and F) The percentage of donor-derived hN+/NeuN+ and hN+/Tbr1+ cells in the total resident NeuN+ and Tbr1+ neurons, respectively, in different brain regions at 6 and 13 months (n = 6 for each time point). Data are presented as box-and-whisker plots. The central horizontal bars indicate the medians, boxes indicate 25th to 75th percentiles, and whiskers indicate the range of the data points. Student’s t tests and 1-way ANOVA were performed to assess the significance. *P < 0.05, **P < 0.01, and ***P < 0.001. Dcx, doublecortin; hiPSC-pNPCs, human induced pluripotent stem cell–derived primitive neural progenitor cells.