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. 2016 Nov 17;1(19):e91015. doi: 10.1172/jci.insight.91015

Figure 2. Vasodilation in the basilar arteries from S-CUL3Δ9 mice.

Figure 2

Dose-dependent relaxation was measured in basilar arteries from nontransgenic (NT) and S-CUL3Δ9 mice. Arteries were pressurized to 60 mmHg and precontracted with the thromboxane A2 mimetic (U46619) to 30% internal diameter. Dose-dependent relaxation in response to acetylcholine (A, n = 5), angiotensin 1–7 (B, n = 4–6), sodium nitroprusside (C, n = 3–4), low-dose potassium chloride (KCl) (D, n = 7), cromakalim (E, n = 7), and nifedipine (F, n = 7) was assessed. Error bars represent the mean ± SEM. *P < 0.05 by 2-way repeated-measure ANOVA.