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. 2016 Nov 17;1(19):e91015. doi: 10.1172/jci.insight.91015

Figure 3. Vasoconstriction in the basilar arteries from S-CUL3Δ9 mice.

Figure 3

Dose-dependent vasoconstriction of the basilar arteries from nontransgenic (NT) and S-CUL3Δ9 mice. Arteries were equilibrated for 30 minutes at 60 mmHg under no-flow conditions, and vasoconstriction responses to angiotensin II (A, n = 7), phenylephrine (B, n = 7), endothelin-1 (C, n = 7–10), potassium chloride (D, n = 3–5), 5-hydroxytryptamine hydrochloride (5-HT or serotonin) (E, n = 7), and the thromboxane A2 mimetic (U46619) (F, n = 3) were assessed. Error bars represent the mean ± SEM. *P < 0.05 by 2-way repeated-measure ANOVA.