Figure 3. ML372 increases SMN protein levels in SMNΔ7 spinal muscular atrophy (SMA) mice.

Protein lysates of (A) brain, (B) spinal cord, and (C) muscle tissues (50–100 μg) from vehicle- or ML372-treated SMNΔ7 SMA mice were resolved by 10% SDS-PAGE. Densitometry analysis is shown as the mean ± SEM (n = 6, ***P < 0.001). P values were determined by unpaired 2-tailed Student’s t test.