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. 2016 Nov 17;1(19):e90064. doi: 10.1172/jci.insight.90064

Figure 4. Whole-body imaging of tumor growth by luminescence and DOTATOC uptake by PET/CT.

Figure 4

(A) Tumor burden from day of intravenous tumor xenograft via tail vein (X0) and 21 days after (X21) was visualized and quantified by bioluminescence. (B–D) Transverse CT-only, PET-only, and PET/CT superimposed images are shown alongside a coronal view of the entire mouse body. PET images are drawn in indicated ranges. Ex vivo fluorescence images of lungs and liver are shown together with flow cytometry analysis of the CD3+ (T cell) and GFP+ (tumor cell) populations of the same lungs are also shown (C and D). Each PET/CT image is representative of at least 3 independent experiments. SS, SSTR2-transduced T cells; RR, R6.5-CAR–transduced T cells; no T, no T cell treatment.