Supplementary Table 1.
Comparison of hematological parameters on the basis of alpha globin genotype in severe Plasmodium falciparum patients with sickle cell anemia.
| Parameters | Normal alpha globin genotype (αα/αα) N=17 | Heterozygous Alpha thalassemia (−α/αα) N=20 | Homozygous Alpha thalassemia (−α/−α) N=9 | p value |
|---|---|---|---|---|
| Complete blood counts | ||||
| Hemoglobin (g/dL) | 7.7±1.8 | 7.1±2.6 | 7.1±2.6 | 0.741 |
| WBC (103 /μl) | 8.1±3.8 | 10.2±7.8 | 8.4±5.7 | 0.133 |
| RBC (106 /μl) | 2.9±0.5 | 3.0±1.2 | 3.0±0.6 | 0.717 |
| MCV (fL) | 87.3±12.0 | 78.6±13.0 | 71.0±7.8 | 0.009 |
| MCH (pg) | 28.9±3.9 | 25.7±3.8 | 25.0±3.7 | 0.017 |
| MCHC (g/dL) | 32.0±2.3 | 31.8±2.2 | 31.3±1.9 | 0.631 |
| Platelets (103 /μl) | 197.2±91.1 | 192.9±157.8 | 179.7±70.2 | 0.554 |
| Biochemical parameters | ||||
| Glucose (U/L) | 106.0±32.6 | 105.4±28.7 | 87.9±45.2 | 0.657 |
| Urea (mg/dL) | 34.2±22.3 | 36.3±25.6 | 46.2±41.7 | 0.094 |
| Creatinine (mg/dL) | 1.41±0.99 | 0.94±0.8 | 1.5±0.9 | 0.064 |
| SGOT (U/L) | 74.2±40.5 | 71.6±56.0 | 54.0±28.8 | 0.295 |
| SGPT (U/L) | 54.3±40.0 | 43.8±34.0 | 40.6±12.7 | 0.771 |
| Bil-T (mg/dL) | 3.1±1.7 | 4.2±2.7 | 3.8±1.8 | 0.301 |
| Bil-D (mg/dL) | 1.1±0.6 | 1.0±0.9 | 1.3±0.6 | 0.253 |
| Hb Variants by HPLC | ||||
| HbA2 (%) | 2.77±0.4 | 2.7±0.8 | 2.9±0.5 | 0.796 |
| HbF (%) | 19.7±3.9 | 18.3±5.2 | 17.4.1±3.7 | 0.635 |
| HbS (%) | 75.0±3.6 | 76.2±5.3 | 75.9±1.5 | 0.765 |
WBC, white blood corpuscle; RBC, Red blood corpuscle; MCV, mean corpuscular volume; MCH, mean corpuscular Hb; MCHC, mean corpuscular Hb concentration; HCT, hematocrit; SGOT, Aspartate transaminase; SGPT, alanine transaminase; Bil-T, bilirubin total; Bil-D, bilirubin direct; LDH, lactate dehydrogenase. Comparison between the groups were made by one way analysis of variance by using SPSS version 16.0 for window as statistical software.