Table 1.

The international recommendations for the screening of altered glucose homeostasis in transfusion depended on thalassemia major.

References	Recommendations
TIF (Guidelines for the Management of Transfusion Dependent Thalassaemia (TDT), 3rd edition, 2014)	OGTT: Q 1 y starting at puberty and FBG every 3 months
USA (Standards of Care Guidelines for Thalassemia, 2012)	FPG: Q 6 mo starting at 5 y OGTT: at 10, 12, 14, 16 y then Q 1 y or as indicated by FPG If FPG is greater than 110 mg/dl an oral OGTT is indicated
Canada (Guidelines for the Clinical Care of Patients with Thalassemia in Canada, 2009)	FPG: Q 6 mo starting at puberty
UK (Standards for the Clinical Care of Children and Adults with Thalassaemia in the UK, 2008)	FPG: Q 3–6 mo starting at puberty or starting at 10 y if positive family history OGTT: Q 1 y starting at puberty or starting at 10 y if positive family history
Australia (Int Med J 2010 ; 40:689–96)	Yearly fasting blood glucose after puberty Proceed to 75g OGTT if indicated
Malaysia (Management of transfusion dependent thalassaemia, 2009)	FPG or a 2 hour OGTT should be performed annually on thalassaemia patients > 10 years old.
I-CET (Indian J Endocrinol Metab 2013;17:8–18)	FPG annually from the age of 5 years. A 2-h OGTT, preferably combined with insulin secretion determination, should be performed at 10, 12, 14, and 16 years of age and annually thereafter. If fasting serum glucose is >110 mg/dl, OGTT is indicated independently of patient’s age

Legend: TIF: Thalassaemia International Federation; Q: every; mo: month; y: year; I-CET: International Network of Clinicians for Endocrinopathies in Thalassemia; FPG: Fasting Plasma Glucose; OGTT: Oral Glucose Tolerance Test.