Table 4.
Patients' Perceptions of the Benefits, Risks, Commitment, and Cure Associated With Phase 1 Trials on the Pre‐ and Postconsultation Questionnaires
| Question | Response | Preconsultation Questionnaire (n = 396) | Postconsultation Questionnaire (n = 301) |
|---|---|---|---|
| Benefit: tumor response, No. (%) | Available data | 384 (97.0) | 301 (100) |
| Shrink | 164 (42.7) | 141 (46.8) | |
| Same | 24 (6.3) | 32 (10.6) | |
| Grow | 1 (0.3) | 4 (1.3) | |
| Do not know | 195 (50.8) | 124 (41.2) | |
| Risks, No. (%) | |||
| Side effects | Available data | 351 (88.6) | 288 (95.7) |
| Mild | 63 (17.9) | 46 (16.0) | |
| Moderate | 248 (70.7) | 222 (77.1) | |
| Severe | 40 (11.4) | 20 (6.9) | |
| Side effects vs chemotherapy | Available data | 366 (92.4) | 296 (98.3) |
| Better | 91 (24.9) | 97 (32.8) | |
| Same | 223 (60.9) | 160 (54.1) | |
| Worse | 38 (10.4) | 29 (9.8) | |
| No prior chemotherapy | 14 (3.8) | 10 (3.4) | |
| Commitment, No. (%) | |||
| Hospital visits | Available data | 340 (85.9) | 299 (99.3) |
| Once a week | 169 (49.7) | 278 (93.0) | |
| Once a month | 153 (45.0) | 19 (6.4) | |
| Less than monthly | 18 (5.3) | 2 (0.7) | |
| Willingness to enter trial | Available data | 383 (96.7) | 299 (99.3) |
| Yes | 274 (71.5) | 252 (84.3) | |
| No | 2 (0.5) | 4 (1.3) | |
| Do not know | 107 (27.9) | 43 (14.4) | |
| Cure: expectation that trial will cure cancer, No. (%) | Available data | Not applicable | 300 (99.7) |
| Yes | Not applicable | 42 (14.0) | |
| No | Not applicable | 146 (48.7) | |
| Do not know | Not applicable | 112 (37.3) |