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. 2016 Oct 18;240(4):472–483. doi: 10.1002/path.4806

Figure 1.

PATH-4806-FIG-0001-b

(A) Clinical scoring of behaviour, mobility, weight loss, mouse grimace, evidence of joint inflammation and duration of joint swelling (as outlined in supplementary material, Table S2) in TNF‐Tg and WT littermate controls between 5 and 9 weeks of age (N = 6 per group). (B) mRNA abundance (AU) of 11β‐HSD1 determined by RT‐qPCR in tibialis anterior muscles isolated from TNF‐Tg and WT controls at 9 weeks (N = 6 per group). (C) Rate of corticosterone generation by ex vivo biopsies of whole quadriceps muscles isolated from TNF‐Tg and WT controls following incubation for 16 h with DHC, determined by scanning thin‐layer chromatograms (N = 6 per group). Values are expressed as mean ± SE. Statistical significance was determined with Student's unpaired t‐test. *p < 0.05, **p < 0.005, ***p < 0.0005.