Extended Data Table 3.

Concentrations of Abi and its metabolites in a phase II clinical trial (NCT01393730).

Patient		#1	#2	#3	#4	#5	#6	#7	#8	#9	#10	#11	#12	#13	#14	#15	#16
Abi	cycle 3	439.46	64.74	210.65	447.29	80.78	195.53	117.58	79.58	135.63	200.93	190.73	320.19	66.11	177.31	131.86	205.48
	cycle 4	1049.04	136.18	95.97	400.55	1399.54	288.80	214.26	207.19	148.05	393.35	219.20	569.72	173.93	203.84	178.06	289.94
	cycle 7	1767.26	130.53	268.79	883.07	112.89	174.05	310.03	127.05	204.86	52.92	220.11	184.44	69.55	215.29	59.88	112.91
D4A	cycle 3	14.83	2.78	11.80	8.89	7.24	12.32	17.23	4.01	10.62	19.11	4.95	11.78	5.23	10.79	11.83	5.91
	cycle 4	34.24	8.83	7.75	13.86	34.49	28.84	23.70	13.01	11.01	16.71	11.91	32.84	12.35	13.09	17.91	10.73
	cycle 7	69.00	8.32	13.64	36.14	15.61	18.63	17.47	7.96	15.60	4.98	10.89	11.01	7.04	32.40	10.64	6.71
3-keto-5α-Abi	cycle 3	44.53	13.29	26.07	16.96	17.46	23.66	22.70	19.74	29.27	38.73	25.28	34.24	21.78	27.32	14.79	36.98
	cycle 4	1.73	4.28	1.78	0.80	3.53	1.53	2.89	0.94	2.04	1.95	0.91	1.64	8.36	3.44	8.44	2.80
	cycle 7	4.34	0.49	0.71	8.97	9.43	0.81	1.41	0.61	13.65	0.56	0.86	0.80	4.86	11.30	6.95	5.05
3α-0H-5α-Abi	cycle 3	15.81	4.45	4.04	3.80	4.53	5.65	4.12	4.86	8.80	9.57	5.56	8.82	5.52	6.16	2.69	3.27
	cycle 4	0.22	0.01	0.18	0.14	0.77	0.35	0.53	0.16	0.52	0.51	0.08	0.01	1.85	0.48	1.91	0.28
	cycle 7	0.84	0.00	0.00	2.45	1.35	0.05	0.00	0.00	2.81	0.08	0.00	0.12	0.98	1.77	1.92	0.49
3β-0H-5α-Abi	cycle 3	5.15	1.31	2.31	2.26	3.25	2.00	1.21	1.63	2.75	3.43	1.55	2.87	2.54	5.81	3.89	1.06
	cycle 4	0.31	0.03	0.60	0.21	2.16	0.09	0.31	0.06	0.32	0.20	0.09	0.17	1.17	1.93	3.83	0.16
	cycle 7	0.59	0.01	0.13	4.04	2.32	0.04	0.17	0.07	3.22	0.05	0.12	0.12	0.50	5.59	2.69	0.31
3-keto-5β-Abi	cycle 3	15.63	6.24	93.39	31.14	55.55	12.21	39.43	12.83	52.75	24.97	23.05	25.00	18.55	57.78	78.37	73.90
	cycle 4	53.05	20.41	41.95	43.95	65.31	24.55	51.38	58.97	24.22	63.34	26.42	36.53	28.47	60.61	73.60	127.48
	cycle 7	141.23	17.17	42.09	75.30	101.40	25.41	24.44	24.65	47.59	20.24	34.29	18.47	29.70	205.11	56.29	102.62
3α-0H-5β-Abi	cycle 3	41.95	14.63	86.05	44.46	70.25	19.57	37.12	21.94	86.71	31.06	31.93	42.80	33.90	98.26	76.44	28.59
	cycle 4	42.31	36.79	55.14	27.67	34.26	34.66	70.21	53.53	75.32	44.13	31.55	76.59	42.91	39.17	68.02	36.96
	cycle 7	110.85	29.24	63.35	99.70	48.28	35.00	37.37	38.95	57.38	24.67	46.16	34.37	33.17	142.07	68.89	37.41
3β-0H-5β-Abi	cycle 3	35.68	18.41	121.85	96.16	129.09	23.92	33.38	33.95	103.67	59.47	41.23	65.71	31.22	216.92	127.26	48.69
	cycle 4	36.33	40.71	115.43	54.54	50.89	35.06	72.74	78.52	82.78	77.29	35.08	83.37	39.21	125.80	114.74	71.33
	cycle 7	95.93	26.97	80.34	180.42	114.67	40.48	41.48	52.28	73.76	40.39	51.22	47.96	42.08	387.83	106.73	82.47