Table 2.

Overlap of marker proteins up-regulated by daptomycin with the proteome response library

Marker protein	Daptomycin	Nisin	Gallidermin	Mersacidin	Valinomycin	Gramicidin A	Gramicidin S	MP196	Aurein 2.3
LiaH (CWB marker)	x	x	x	x			x	x	x
LiaR	x
PspA (CM marker)	x	x	x		x	x	x	x	x
ResD	x
IspH	x
Total markers	8	8	21	13	20	5	17	27	33

CM, cell membrane; CWB, cell wall biosynthesis. LiaH is a specific marker for inhibition of membrane-bound steps of lipid II synthesis, and PspA is a specific marker for membrane stress. Note that in contrast to daptomycin, other membrane-active antibiotics typically have a higher number of total marker proteins.