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. 2016 Oct 25;113(45):E7097–E7105. doi: 10.1073/pnas.1606351113

Fig. 2.

Fig. 2.

Social isolation alters glutamatergic transmission in the mPFC by glucocorticoid activation. (A) (Left) Representative mEPSC traces obtained from layer 2/3 pyramidal neurons in the mPFC of socially isolated or nonisolated juvenile rats. (Right) Graphs depicting the average mEPSC amplitude and frequency (n = 6 neurons nonisolated and n = 10 neurons isolated). (B) (Left) Representative mEPSC traces obtained from layer 2/3 pyramidal neurons in the mPFC of RU486-treated socially isolated rats, vehicle-treated controls, and RU486 treated controls. (Right) Graphs depicting the average mEPSC amplitude and frequency (n = 9 neurons nonisolated with vehicle, n = 8 neurons isolated with RU486, and n = 6 neurons nonisolated with RU486) [amplitude, ANOVA F(2, 20) = 0.070; frequency, ANOVA F(2, 20) = 1.072]. *P < 0.05 (A, unpaired Student’s t test and B, ANOVA post hoc Fisher's PLSD test). Error bars represent SEM. n.s., not statistically significant.