Fig. S7.

Distribution of DMCs in WT and Mili^−/− brain that had hypomethylated CpGs in the promoter regions of full-length LINE1s in Mili^−/− hippocampi. Raw data plot of all consensus CpGs in WT and Mili^−/− hippocampi (and corresponding regions in PFC for comparison) across full-length LINE1 promoter regions that were hypomethylated in Mili^−/− brain tissues. Each dot represents individual CpGs plotted over its distance from LINE1 TSS vs. methylation. Overlapping dots were identified by darker shades. Each rhombus represents the average of at least three data points. Error bar, SEM. Arrowheads represent significant difference in DMCs that exhibited at least 25% methylation difference between WT and Mili^−/− tissues. An absence of significance in PFC was attributed to the filtering of data points while taking into account sex consensus sites. Also, note an increased SEM for DMCs in WT PFC.