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. 2016 Oct 26;113(45):12838–12843. doi: 10.1073/pnas.1612746113

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Fig. 3. — Scn8a^N1768D/+ myocytes are hyperexcitable and display increased arrhythmogenecity. (A) Representative traces of DADs recorded in Scn8a^N1768D/+ myocytes (gray) compared with WT (black). (B) The incidence of DADs was significantly increased in Scn8a^N1768D/+ animals compared with WT (P = 0.001). (C) Scn8a^N1768D/+ myocytes have a significant reduction in AP threshold (P = 0.03). For B and C, Scn8a^N1768D/+ (D/+): n = 10, N = 4; Scn8a^+/+ (WT): n = 8, N = 6. PCL, pacing cycle length. *P < 0.05 vs. WT.