Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Working myocytes from Scn8aN1768D/+ mice display hyperexcitability and ectopic beating. (A) Representative traces from WT (black) and Scn8aN1768D/+ (gray) myocytes. Black arrows represent pacing stimulus. No differences in (B) cell length (P = 0.72) or (C) relaxation times (P = 0.36) were observed. (D) Increased incidence of irregular beats in Scn8aN1768D/+ mice (P < 0.001). Data are presented at 0.5 Hz. Scn8a+/+ (WT): n = 21, N = 5; Scn8aN1768D/+ (D/+): n = 20, N = 5. *P < 0.05 vs. WT.
