Table S2.

Whole-cell I_Na properties

Measurement	WT (n = 8, N = 3)	D/+ (n = 10, N = 4)	P Value
Peak INa	−36.20 ± 0.80	−30.98 ± 5.02	0.55
Peak INa, mV	−45.63 ± 2.40	−47.50 ± 2.71	0.62
INa, P at −45 mV	−0.73 ± 0.35	−1.08 ± 0.38	0.51
Activation
V50	−56.89 ± 0.72	−58.09 ± 0.72	0.24
Slope	5.85 ± 0.63	6.03 ± 0.62	0.84
Inactivation
V50	−89.09 ± 0.59	−89.38 ± 0.76	0.77
Slope	8.06 ± 0.52	8.86 ± 0.68	0.35
INa decay (τFast)
−50 mV	2.45 ± 0.26	2.21 ± 0.17	0.43
−40 mV	1.80 ± 0.11	1.66 ± 0.18	0.55
−30 mV	1.67 ± 0.35	1.34 ± 0.14	0.36
−20 mV	1.51 ± 0.41	1.07 ± 0.10	0.26
INa decay (τSlow)
−50 mV	9.68 ± 1.97	8.60 ± 1.90	0.70
−40 mV	6.28 ± 1.62	4.45 ± 0.53	0.26
−30 mV	3.66 ± 0.83	4.52 ± 1.29	0.60
−20 mV	6.80 ± 2.39	4.36 ± 1.23	0.35