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. 2016 Oct 26;113(45):12838–12843. doi: 10.1073/pnas.1612746113

Table S2.

Whole-cell INa properties

Measurement WT (n = 8, N = 3) D/+ (n = 10, N = 4) P Value
Peak INa −36.20 ± 0.80 −30.98 ± 5.02 0.55
Peak INa, mV −45.63 ± 2.40 −47.50 ± 2.71 0.62
INa, P at −45 mV −0.73 ± 0.35 −1.08 ± 0.38 0.51
Activation
 V50 −56.89 ± 0.72 −58.09 ± 0.72 0.24
 Slope 5.85 ± 0.63 6.03 ± 0.62 0.84
Inactivation
 V50 −89.09 ± 0.59 −89.38 ± 0.76 0.77
 Slope 8.06 ± 0.52 8.86 ± 0.68 0.35
INa decay (τFast)
 −50 mV 2.45 ± 0.26 2.21 ± 0.17 0.43
 −40 mV 1.80 ± 0.11 1.66 ± 0.18 0.55
 −30 mV 1.67 ± 0.35 1.34 ± 0.14 0.36
 −20 mV 1.51 ± 0.41 1.07 ± 0.10 0.26
INa decay (τSlow)
 −50 mV 9.68 ± 1.97 8.60 ± 1.90 0.70
 −40 mV 6.28 ± 1.62 4.45 ± 0.53 0.26
 −30 mV 3.66 ± 0.83 4.52 ± 1.29 0.60
 −20 mV 6.80 ± 2.39 4.36 ± 1.23 0.35