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F901318 inhibits A. fumigatus DHODH in vitro. Recombinant A. fumigatus DHODH (A) and human DHODH (B) were incubated in the presence and absence of varying concentrations of F901318 and teriflunomide. The activity of the enzymes was measured for each drug concentration, and the percent inhibition compared with no drug controls was calculated.
