Fig. S2.

DHODH is an enzyme of pyrimidine biosynthesis. (A) Pathway of de novo pyrimidine biosynthesis in A. fumigatus. Enzyme names, classification (according to the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology; www.chem.qmul.ac.uk/iubmb/enzyme/), and predicted A. fumigatus genes (from KEGG; www.genome.jp/kegg/ and EnsemblFungi; www.fungi.ensembl.org/index.html/) are listed next to each step of the pathway. (B) Reaction catalyzed by DHODH. In mammals and many fungi, DHODH is located at the mitochondria, where a transmembrane domain anchors the enzyme to the outside of the inner mitochondrial membrane. In the intermembrane space, DHODH catalyzes the oxidation of dihydroorotate to orotate. FMN and ubiquinone from the mitochondrial membrane (coenzyme Q) act as electron acceptors in the reaction.