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Effect on MIC of repeated exposure of A. fumigatus to F901318 or voriconazole. A. fumigatus 210 conidia were inoculated on Sabouraud agar. Then 100 µL of 500 µg/mL F901318 (blue circles) or voriconazole (red squares) was dispensed into a well in the center of the plate and allowed to diffuse. After incubation at 35 °C for 4 d, conidia were collected from the margins of growth and used to inoculate the next plate. After every five passages, the MIC of the conidia was determined.
