Table 1.
Antifungal potency of F901318 and other antifungal drugs against the major Aspergillus species
| Drug | Parameter | A. fumigatus (n = 55) | A. terreus (n = 21) | A. flavus (n = 19) | A. niger (n = 19) |
| F901318 | MIC mean, µg/mL | 0.029 | 0.014 | 0.021 | 0.031 |
| MIC range, µg/mL | 0.008–0.06 | 0.004–0.03 | 0.015–0.06 | 0.015–0.06 | |
| Amphotericin B | MIC mean, µg/mL | 1.55 | 2.07 | 1.39 | 0.46 |
| MIC range, µg/mL | 0.5–2 | 1–4 | 1–2 | 0.25–1 | |
| Caspofungin | MEC* mean, µg/mL | 0.096 | 0.112 | 0.06 | 0.062 |
| MEC* range, µg/mL | 0.06–0.12 | 0.06–0.12 | 0.06 | 0.06–0.12 | |
| Voriconazole | MIC mean, µg/mL | 0.69 | 0.59 | 0.96 | 0.77 |
| MIC range, µg/mL | 0.25–16 | 0.25–1 | 0.5–1 | 0.5–16 |
The MICs (in µg/mL) of F901318, amphotericin B, and voriconazole were determined for the Aspergillus spp. indicated (n, number of different strains tested). *For caspofungin, the MEC is shown, because growth is not completely inhibited with this drug. Data are displayed as the geometric mean of the MICs and the range of MIC from lowest to highest for the strains of a particular species.