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. 2016 Oct 25;113(45):E7020–E7029. doi: 10.1073/pnas.1608162113

Fig. 4.

Fig. 4.

Remodeling of H3K36me3 and H3K27me1 marking from EE to L3. (A) Border H3K36me3 is reduced from EE to L3. Plots show heatmaps of H3K36me3 and H3K27me3 signals centered at borders pseudoscaled at 2.5 kb, and show 5 kb into regulated domains (Left) and 5 kb into active domains (Right). (B) H3K27me1 at borders is remodeled from EE to L3. Upper plots average signals centered at borders pseudoscaled at 2.5 kb, with 5 kb into regulated domains (Left) and 5 kb into active domains (Right). Lines show mean signal, darker-filled areas show SE, and lighter-filled areas are 95% confidence intervals. Gray vertical lines indicate edges of the border region. Lower panels show heatmaps of the same regions. Plots at bottom show heatmaps of H3K27me1 signals centered at borders pseudoscaled at 2.5 kb, and show 5 kb into regulated regions (Left) and 5 kb into active regions (Right). Heatmap rows are sorted by decreasing mean signal and show the same regions and order.