Table 2.

E2 residue clusters 1–12, and average alanine mutant percent binding within antigenic domains (and average for all antigenic domains) for each cluster

Cells with average (Avg) percent binding are colored as in Fig. 1. Epitope residues for antigenic domains A–E noted in previous studies (12, 25, 39, 57) are in bold. Clusters ordered according to cluster size; clusters 13–16, each containing 30 or more residues, are omitted here for brevity and provided in SI Appendix, Table S2. Cluster numbers in bold have bootstrapping P value ≥ 95%.