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Mechanism of action of sofosbuvir and daclatasvir 3, 4. After entering hepatocytes, the viral genome of HVC is translated into a single polypeptide which is subsequently cleaved into viral proteins that are essential for HVC replication and viral assembly. Sofosbuvir inhibits NS5B RNA dependent RNA polymerase and daclatasvir is an inhibitor of NS5B, both inducing disruption of viral replication
