Table 1. OVs used in PNST pre-clinical models.

Abbreviations: GFP, enhanced green fluorescent protein; h, human; IL, interleukin; LacZ, β-galactosidase; NIS, sodium/iodide symporter; pro, promoter; TIMP3, tissue inhibitor of metalloproteinases 3; IE4/5, immediate-early gene 4/5.

Oncolytic Virus	Genetic Modifications	Transgene	Drug Combination	PNST Model	Ref.
oHSV
G47Δ	γ34.5Δ, ICP6-, ICP47Δ, LacZ+			MPNST orthotopic sciatic nerve, Transgenic schwannoma, Subcutaneous schwannoma	49, 50, 57, 65
G207	γ34.5Δ, ICP6-			Subcutaneous and intraperitoneal human MPNST in athymic mice	52, 54
NV1023	UL56Δ/1 copy of ICP0, ICP4 and γ34.5			Perineural invasion model in sciatic nerve	60, 61
G207	γ34.5Δ, ICP6-		Erlotinib	Subcutaneous and intraperitoneal: human MPNST in athymic mice	54
rQT3	γ34.5Δ, ICP6-	IE4/5pro-TIMP3, ICP6-GFP fusion in ICP6		MPNST xenograft models	55
hrR3	ICP6-, LacZ+			Subcutaneous and intraperitoneal human MPNST in athymic mice	54
oHSV-MDK-34.5	Mdk pro-γ34.5 and ICP6-GFP fusion in ICP6			Subcutaneous human MPNST in athymic mice	56
G47Δ-PF4	γ34.5Δ, ICP6-, ICP47Δ, ICP47pro-Us11	PF4		Subcutaneous MPNST xenograft, MPNST orthotopic sciatic nerve in immunocompetent mice	57
G47Δ-dnFGFR	γ34.5Δ, ICP6-, ICP47Δ, ICP47pro-Us11	dnFGFR		Subcutaneous MPNST xenograft, MPNST orthotopic sciatic nerve in immunocompetent mice	64
G47Δ-mIL12	γ34.5Δ, ICP6Δ	mIL-12		MPNST orthotopic sciatic nerve in immunocompetent mice	65
Other OVs
Ad5/3-D24-GMCSF	Ad5/3 fiber, E1A 24-bpΔ, E3Δ	hGMCSF	doxorubicin, ifosfamide	leiomyosarcoma cells in Syrian hamster	74
MV-NIS	Edmonston vaccine strain	NIS		Subcutaneous human MPNST in athymic mice	77
VSV-rp30a	Disruption of gene order			In vitro human MPNST cell lines	81