Table 3.
Measures of cardiac structure and function according to diabetes control. Results from echocardiographic ancillary study of The Hispanic Community Health Study/Study of Latinos (ECHO-SOL).
| Cardiac Structure | Systolic Function | Diastolic Function | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Uncontrolled*
n=244 (47%) |
Controlled n=279 (53%) |
P-Value | Uncontrolled*
n=244 (47%) |
Controlled n=279 (53%) |
P-Value | Uncontrolled*
n=244 (47%) |
Controlled n=279 (53%) |
P-Value | |||
| LV Mass Index 2.7 | End Diastolic Volume, MOD-biplane(ml) | E/e' Lateral Ratio | |||||||||
| M1 | 45.09±0.56 | 44.53±0.26 | 0.37 | 81.03±1.07 | 82.49±0.47 | 0.21 | 10.06±0.11 | 9.53±0.09 | 0.0002 | ||
| M2 | 44.02±0.55 | 43.48±0.38 | 0.35 | 81.48±1.30 | 84.44±1.03 | 0.07 | 9.89±0.12 | 9.16±0.17 | <0.0001 | ||
| M3 | 43.34±1.05 | 40.54±0.59 | <0.0001 | 77.89±1.83 | 78.93±0.96 | 0.56 | 9.74±0.32 | 9.34±0.27 | 0.16 | ||
| LV mass (grams/m2) | End Systolic Volume, (MOD-biplane±ml) | E/e' Septal Ratio | |||||||||
| M1 | 88.95±1.01 | 86.88±0.52 | 0.07 | 34.43±0.64 | 33.55±0.21 | 0.19 | 13.51±0.14 | 12.67±0.08 | <0.0001 | ||
| M2 | 87.54±1.13 | 84.95±0.76 | 0.03 | 34.54±0.72 | 34.52±0.55 | 0.99 | 13.67±0.14 | 12.71±0.18 | <0.0001 | ||
| M3 | 85.62±1.82 | 79.17±1.09 | <0.0001 | 31.74±0.97 | 31.23±0.48 | 0.60 | 12.53±0.34 | 12.17±0.25 | 0.20 | ||
| LV Posterior Wall at diastole (cm) | Ejection Fraction (MOD-biplane)% | LA Volume Index | |||||||||
| M1 | 0.94±0.01 | 0.92±0.004 | 0.05 | 58.21±0.25 | 59.36±0.12 | <0.0001 | 22.60±0.35 | 22.64±0.14 | 0.90 | ||
| M2 | 0.92±0.01 | 0.88±0.01 | 0.002 | 58.54±0.27 | 59.39±0.21 | 0.002 | 22.91±0.33 | 23.13±0.31 | <0.0001 | ||
| M3 | 0.89±0.02 | 0.84±0.01 | <0.0001 | 59.42±0.46 | 60.04±0.27 | 0.13 | 21.16±0.80 | 20.82±0.46 | 0.57 | ||
| Inter-ventricular Septal Diameter (cm) | Fractional Shortening (%) | Lateral Peak e' Velocity (cm/s) | |||||||||
| M1 | 1.17±0.01 | 1.11±0.01 | <0.0001 | 29.55±0.24 | 29.70±0.13 | 0.62 | 8.04±0.12 | 8.60±0.07 | <0.0001 | ||
| M2 | 1.16±0.01 | 1.10±0.01 | <0.0001 | 29.32±0.31 | 29.47±0.21 | 0.62 | 8.22±0.12 | 9.12±0.12 | <0.0001 | ||
| M3 | 1.13±0.01 | 1.03±0.01 | <0.0001 | 30.14±0.43 | 29.35±0.36 | 0.02 | 8.01±0.15 | 8.84±0.12 | <0.0001 | ||
| Relative Wall Thickness | Lateral Peak S Velocity (cm/s) | Medial Peak e' Velocity (cm/s) | |||||||||
| M1 | 0.43±0.004 | 0.41±0.002 | 0.002 | 8.25±0.09) | 8.12±0.05 | 0.14 | 5.85±0.06 | 6.32±0.04 | <0.0001 | ||
| M2 | 0.42±0.003 | 0.39±0.004 | <0.0001 | 8.50±0.10) | 8.50±0.10 | 0.96 | 5.82±0.06 | 6.39±0.06 | <0.0001 | ||
| M3 | 0.40±0.01 | 0.37±0.004 | 0.0001 | 8.41±0.15) | 8.34±0.11 | 0.65 | 5.96±0.09 | 6.63±0.06 | <0.0001 | ||
|
LV Geometry
(Odds Ratios for abnormal vs. normal) |
Stroke Volume (LVOT) ml |
Diastolic Dysfunction
(Odds Ratios for grade I-III vs. normal) |
|||||||||
| M1 | 1.00 | 0.82(0.5-1.4) | 0.44 | 69.04±0.68) | 69.95±0.46 | 0.25 | 1.00 | 0.64(0.4-1.1) | 0.08 | ||
| M2 | 1.00 | 0.77(0.5-1.3) | 0.35 | 71.21±0.84) | 72.35±0.68 | 0.20 | 1.00 | 0.48(0.3-0.9) | 0.02 | ||
| M3 | 1.00 | 0.67(0.3-1.6) | 0.36 | 72.09±1.29) | 69.34±0.90 | 0.002 | 1.00 | 0.96(0.4-2.2) | 0.93 | ||
Model 1: crude
Model 2: age, sex, site, smoking status, alcohol use, physical activity level, body mass index, hypertension and chronic kidney disease
Model 3: sensitivity analyses excluding participants with cardiovascular disease and kidney disease adjusted for age, sex, site, smoking status, alcohol use, physical activity level, body mass index and hypertension
*
Uncontrolled diabetes defined as HbA1c≥7.