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. Author manuscript; available in PMC: 2017 Jan 19.
Published in final edited form as: Anal Chem. 2016 Jan 4;88(2):1230–1237. doi: 10.1021/acs.analchem.5b03541

Figure 5.

Figure 5

Dual probe microdialysis of rat striatum showing effects of AMPH (5 mg/kg, IP) on DA release and other neurochemicals sampled by a concentric microdialysis probe (MD) and microfabricated probe (μFab). Both probe types have similar performance on response to dynamic in vivo chemical changes. Lines indicates when AMPH was present (fractions at 60 and 80 min). Data were converted to percent of baseline measurement to normalize pre-drug levels to 100 percent. Student’s t-test indicates a significant change (*p < 0.05) between basal and post drug levels. Results are the mean ± SEM, n = 3 animals. For other measured neurochemicals, their post drug levels did not significantly change.