Table 5. Optimum levels of independent variables where the desired level of the response variables is predicted to be achieved.

Variables	Goal	Lower limit	Upper limit	Optimum levels				Desirability
				X1	X2	X3	Y
Dose of PH (mg/kg-1 bw)	minimize	5	25
Total number of doses (n)	in range	2	10
Dose interval (h)	in range	12	60
Elevation in total serum bilirubin (mg/dl-1)	maximize	1.78	4.9	11.56	8	24.56	4.06	0.7
Reproducibility
Elevation in total serum bilirubin (mg/dl-1)							3.58 ± 0.47