Table 2.

Anticancer (LC₅₀ in µg/mL) of compounds from 1–6 and their selectivity index (SI).

Compounds	Cytotoxicty (LC50 in µg/mL)		Selectivity Index*
	HeLa cells	Vero cells	HeLa cells	V. cholerae SG24 (1)	V. cholerae CO6	V. cholerae NB2	V. cholerae PC2	S. flexneri SDINT
1	6.33 ± 0.66a	124.72 ± 1.27a	19.70	15.59	7.79	3.89	3.89	7.79
2	6.74 ± 0.27a	158.24 ± 2.86b	23.47	39.56	4.94	9.89	19.78	9.89
3	8.13 ± 0.18b	233.26 ± 3.73c	28.69	466.52	14.57	29.15	466.52	29.15
4	9.21 ± 0.79b	261.14 ± 2.87d	28.35	4.08	2.04	2.04	2.04	4.08
5	2.06 ± 0.23c	195.41 ± 1.79e	94.85	3.05	3.05	6.10	6.10	6.10
6	0.88 ± 0.12d	277.62 ± 1.38f	315.47	4.33	2.16	4.33	2.16	2.16
Paclitaxel	0.57 ± 0.03e	68.51 ± 0.19g	120.19	/	/	/	/	/

/: not determined, SI = LC₅₀ on Vero cells /MIC or LC₅₀ on HeLa cells;

^*SI obtained from average MIC. Each LC₅₀ value represents the mean ± SD (n = 3). In the same column, LC₅₀ values marked with different superscript letters (a-g) are significantly different (p < 0.05).