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. 2016 Aug 2;24(10):1771–1782. doi: 10.1038/mt.2016.136

Figure 2.

Figure 2

Kidney laboratory test results from nonhuman primates and healthy human volunteers treated with multiple doses up to 13 and 6 weeks, respectively, by dose group. (a,b) Serum creatinine levels in nonhuman primates (ULN = 1.1 mg/dl) and healthy human volunteers (LLN = 0.5 and ULN = 1.4 mg/dl); (c,d) Blood nitrogen urea (BUN) levels in nonhuman primates (ULN = 32 mg/dl) and healthy human volunteers (LLN = 5 and ULN = 22 mg/dl); (e) Glomerular filtration rate (GFR) in healthy human volunteers. GFR was derived using the MDRD equation: 170 × (serum creatinine (mg/dl))−0.999 × (age)−0.176 × (0.762, if subject is female) × (1.180, if subject is black) × (serum urea nitrogen (mg/dl))−0.170 × (serum albumin (g/dl))0.318. Data presented is the mean ± SE. Each data point represents data from at least 10 subjects, four ASOs and four independent studies. Dashed lines indicate the laboratory test reference range values and yellow y-axis markers indicate the event criteria. A tabulated summary of results is provided in Supplementary Table S4. ULN, upper-limit-of-normal; LLN, lower-limit-of-normal; ASO, antisense oligonucleotide.