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. 2016 Aug 2;24(10):1771–1782. doi: 10.1038/mt.2016.136

Figure 5.

Figure 5

Complement activation during the 24-hour period after subcutaneous injection of study drug in nonhuman primates and healthy human volunteers treated with multiple doses up to 13 and 6 weeks, respectively, by dose group. (a,b) Complement split product, Bb, in nonhuman primates (ULN = 2.8 μg/ml) and healthy human volunteers (ULN = 1.49 μg/ml). Data presented is the mean ± SE. Each data point represents data from at least 10 subjects and four ASOs. Dashed gray lines indicate the upper limit of the reference range and the yellow y-axis markers indicate the event criteria. ULN, upper-limit-of-normal; ASO, antisense oligonucleotide.