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. 2016 Aug 30;24(10):1726–1733. doi: 10.1038/mt.2016.151

Figure 2.

Figure 2

The newly identified lncRNA-MSR in chondrocytes is stimulated by mechanical stress. (a) The expression of lncRNA-MSR in chondrocytes by cyclic tensile strain (CTS) at a magnitude of 5% and 10% was examined using Northern blotting. ACTB was used as an internal control. (b) The chondrocytes were stimulated with mechanical stress for the indicated times. The expression of COL2A1, ACAN, TMSB4, and MMP13 were analyzed using qPCR at 0, 4, 12, and 24 hours (the 0 hour timepoint was used for comparisons). (c) The expression of TMSB4 and lncRNA-MSR in chondrocytes were analyzed using qPCR at the various magnitudes of CTS. (d) The expression of TMSB4 and lncRNA-MSR in chondrocytes were analyzed using qPCR for the various durations of CTS. The results are shown as the mean ± SEM of at least three independent experiments (*P < 0.05, **P < 0.01).