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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: J Neurol. 2016 Oct 11;263(12):2505–2514. doi: 10.1007/s00415-016-8292-z

Table 2.

Relationship between cognitive performance and DTI metrics (MetS group)

VF: animals (T- score) L postcentral gyrus – LD L postcentral gyrus – RD R postcentral gyrus - RD L supramarginal gyrus – LD L supramarginal gyrus - RD L angular gyrus - RD R angular gyrus - MD R angular gyrus - RD
LS
Model–1		 r2adj 0.2 0.3 0.1 0.2 0.2 0.1 0.1 0.3
P 0.003 0.001 0.01 0.005 0.009 0.04 0.02 0.0008
HbA1c 0.04 0.01 0.03 0.05 0.02 NS NS NS
LS
Model–2		 r2adj 0.3 0.4 0.3 0.3 0.3 0.2 0.3 0.4
P 0.006 0.001 0.01 0.004 0.01 0.03 0.02 0.0006
HbA1c NS NS NS NS NS NS NS NS
LS
Model–3		 r2adj 0.2 0.3 0.2 0.2 0.2 NS 0.1 0.3
P 0.003 0.001 0.01 0.007 0.009 NS 0.02 0.001
HbA1c 0.04 0.01 0.03 0.03 0.01 0.05 NS 0.03
LS
Model-4		 r2adj 0.2 0.3 0.1 0.2 0.2 0.1 0.1 0.3
P 0.003 0.001 0.01 0.007 0.009 0.04 0.02 0.001
HbA1c NS 0.02 0.04 0.03 0.02 NS NS 0.04

Model 1= adjusted for age, sex, HbA1c, and mean BP; Model 2= adjusted for age, HbA1c, mean BP and the global WMHs volume; Model 3= adjusted for age, HbA1c, mean BP, and the presence of hyperlipidemia; Model 4= adjusted for age, HbA1c, mean BP and BMI. Abbreviations: Right (R); Left (L); Verbal fluency (VF); Fractional anisotropy (FA), Mean diffusivity (MD), Axial diffusivity (LD), Radial diffusivity (RD); Least squares (LS).