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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Prog Retin Eye Res. 2016 Jun 11;55:1–31. doi: 10.1016/j.preteyeres.2016.06.001

Figure 1. Timeline of human genetics and genomic technologies.

Figure 1

NGS based applications have been utilized widely in vision and other biomedical research. A. From the discovery of DNA molecule until today, substantial scientific and technical advancements in human genetics and eye field are presented in a chronological order. The first NGS report was published a decade after the launch of human genome project. B. Cumulative number of biomedical research papers based on NGS technologies from 2008 to 2015 in PubMed database. We believe the number of scientific reports based on NGS technologies will continue to increase as NGS become more available and affordable. C. Profiling genomic variations is more employed than expression and genome binding profiling in vision research studies. As of December 2015, the total number of NGS based studies doubled in the eye field compared to two years ago. PCR, polymerase chain reaction; RP, retinitis pigmentosa; HGP, human genome project; NGS, next generation sequencing; AMD, age-related macular degeneration; GWAS, genomewide association study.