Table 1.
Demographic and clinical information (n =80)
| Total (n =80)
|
Bipolar (n =31)
|
MDD (n = 49)
|
P-value | ||||
|---|---|---|---|---|---|---|---|
| n | % | n | % | n | % | ||
| Gender (female) | 41 | 51 | 20 | 65 | 21 | 43 | 0.07 |
| Family history of mood disoders | 69 | 86 | 28 | 90 | 41 | 84 | 0.52 |
| Mean | S.d. | Mean | S.d. | Mean | S.d. | P-value | |
|
| |||||||
| Age | 44.3 | 12.1 | 46.1 | 11.0 | 43.1 | 12.8 | 0.28 |
| Age of onset (years) | 18.5 | 10.2 | 17.2 | 7.3 | 19.4 | 11.6 | 0.34 |
| Current episode (months) | 44.9 | 90.5 | 18.4 | 21.0 | 61.8 | 111.9 | 0.04 |
| Duration of Illness (years) | 25.8 | 12.4 | 28.9 | 10.6 | 23.9 | 13.2 | 0.08 |
| Previous episodes | 32.7 | 40.1 | 43.2 | 37.7 | 25.8 | 40.5 | 0.07 |
| BMI | 29.2 | 5.8 | 30.1 | 6.3 | 28.7 | 5.4 | 0.33 |
| HAM-D (baseline) | 21.3 | 4.0 | 21.2 | 3.9 | 21.3 | 4.1 | 0.87 |
| MADRS (baseline score) | 33.3 | 4.7 | 32.8 | 4.4 | 33.5 | 4.9 | 0.54 |
| MADRS (percent change from baseline) | |||||||
| 230 min | − 35.7 | 32.8 | − 40.3 | 32.6 | − 32.8 | 32.9 | 0.32 |
| Day 1 | − 34.2 | 35.4 | − 41.1 | 34.4 | −29.9 | 35.6 | 0.17 |
Abbreviations: BMI, body mass index; HAM-D, Hamilton Depression Rating Scale; MADRS, Montgomery–Asberg Depression Rating Scale; MDD, major depressive disorder.