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. 2016 Nov 17;7:507. doi: 10.3389/fimmu.2016.00507

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Copyright © 2016 Ogonek, Kralj Juric, Ghimire, Varanasi, Holler, Greinix and Weissinger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Development of natural and induced regulatory T cells. Natural regulatory T cells (nTregs) are derived from the thymus and are characterized by the co-expression of CD4, high expression of CD25 and FoxP3, and are collectively represented as CD4⁺CD25⁺FoxP3⁺ Tregs. Induced or adaptive regulatory T cells (iTregs) are generated in the peripheral lymphoid organs in the presence of transforming growth factor beta (TGF-β) and interleukin-2 (IL-2).