Figure 4.

Recovery of CMV-specific cytotoxic T lymphocytes after HSCT. Examples of reconstitution of CMV-specific cytotoxic T lymphocytes (CTLs) after HSCT for CMV-seropositive recipients transplanted from CMV-seropositive donors (R+/D+) (A) and CMV-seropositive recipients transplanted from CMV-seronegative donors (R+D−) (B) are shown. CMV–CTL numbers per microliter of whole blood (left y-axis) were plotted against the time after HSCT (days). The right y-axis shows the number of pp65-positive cells/400,000 leukocytes (detection of CMV-reactivation). The CMV R+D+ patient had a CMV-reactivation by day +39 and responded by an expansion of CMV–CTLs. No significant reconstitution of CMV–CTLs within the CMV R+D− patient was detected until day +100 despite the early CMV reactivation. Adapted from Ref. (136).