Table 3.
Reference | Key information |
---|---|
Altman et al. (146) | First use of MHC tetramers to enumerate and characterize antigen-specific T cells |
Cwynarski et al. (113) | Protection from CMV reactivation with ≥10 CMV–CTL cells/μL blood |
Gratama et al. (142) |
|
Aubert et al. (147) | Less than 20 cells/μL of HLA-A*02 CMV–CTLs predicted episodes of viral replication |
Chen et al. (148) | More than 10–20 cells/μL CMV–CTLs conferred protection against CMV reactivation |
Özdemir et al. (107) | Inability to control CMV reactivation is caused by impaired function of CMV–CTLs rather than an inability to recover sufficient numbers of CMV-specific T cells |
Lacey et al. (149) | CMV-specific cellular immune responses restricted by HLA-B*07 dominated those restricted by HLA-A*02 |
Akiyama et al. (150) | Frequency of HLA-A*24 CMVpp65 tetramer-positive staining correlated with cytotoxicity and IFN-γ production |
Bunde et al. (151) | High frequencies of IFN-γ producing IE-1, but not pp65-specific CD8+ T cells, correlated with protection from CMV disease |
Lilleri et al. (152) | Levels of CD4+ T cells below 1 cell/μL and of CD8+ T cells less than 3 cells/μL did not protect against recurrent CMV infection |
Gratama et al. (153) |
|
Koehl et al. (154) |
|
Giest et al. (155) | HLA-A*24/pp65- and HLA-B*35/pp65-CTLs correlated with protection from CMV reactivation at significantly lower cell levels than HLA-A*01/pp50- and HLA-A*02/pp65-CTLs |
Gratama, et al. (156) | Less than 7 cells/μL of CMV–CTLs during the first 65 days after transplantation was a significant risk factor for CMV-related complications |
Borchers et al. (134) |
|
Lilleri et al. (157) | Combination of CMV–CTL monitoring and viral monitoring can be used to direct preemptive treatment with antiviral drugs |
Borchers et al. (136) |
|
Reused from Ref. (137) by permission from Elsevier, License Number 3922460449459.
MHC, major histocompatibility complex; CMV–CTL, cytomegalovirus cytotoxic T lymphocytes; HLA, human leukocyte antigen; IFNγ, interferon gamma; IE-1, immediate early-1.