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. 2016 Sep 5;39(6):1862–1870. doi: 10.1007/s10753-016-0418-z

Fig. 3.

Fig. 3

Brain I/R injury mice with DM aggravated brain injury and increased the expression of inflammation factors at the same time. ad Analysis of blood–brain barrier damage and inflammation reaction in the process. ac The expression of IL-1β, IL-6, and iNOS mRNA in four groups of brain tissues. d Evans blue extravasation, which represents for the breakdown of blood–brain barrier in each group. n = 5 for each group. Data are presented as mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. NGS normoglycemia sham, NG I/R normoglycemia ischemia/reperfusion, HGS hyperglycemia sham, HG I/R hyperglycemia ischemia/reperfusion.