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. 2016 Sep 5;39(6):1862–1870. doi: 10.1007/s10753-016-0418-z

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — The protective role of anti-HMGB1 mAb in cerebral I/R injury with DM. a–d Analysis of blood–brain barrier damage and inflammation reaction in the process. a–c The expression of IL-1β, IL-6 and iNOS mRNA in 4 groups of brain tissues. d Evans blue extravasation, which represents for the breakdown of blood brain barrier in each group. n = 5 for each group. Data are presented as mean ± SD, *p < 0.05. HGS hyperglycemia sham, HG I/R hyperglycemia ischemia/reperfusion.