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. 2016 Nov 8;4(21):e13016. doi: 10.14814/phy2.13016

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© 2016 EA Pharma Co., Ltd. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Alanine aminotransferase (ALT; hepatitis), hepatic triglycerides (TG; fat accumulation in the liver), hepatic cholesterol (TCHO) and gene expression in the livers of mice fed with steatohepatitis‐inducing high‐fat diet (STHD‐01) and administered pioglitazone, telmisartan, or olmesartan. ALT levels (A), hepatic TG levels (B), and hepatic TCHO levels (C), as well as expression levels of Mcp1 (D), Tnf (E), Cd68 (F), and Acta2 (G) in the liver were determined after feeding with standard diet (SD) or STHD‐01 for 1 week (n = 4–5 in the SD and STHD‐01 groups). Bars represent the means ± standard errors. *P < 0.05, **P < 0.01, ***P < 0.001 compared with the SD group (Student's t‐test). ^# P < 0.05, ^## P < 0.01, ^### P < 0.001 compared with the STHD‐01 group (Dunnett's test).